| Identification | Back Directory | [Name]
LIMK1 inhibitor BMS 4 | [CAS]
905298-84-2 | [Synonyms]
LIMK1 inhibitor BMS 4
LIMK1 inhibitor BMS 4 - BMS 4
1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea
Urea, N-ethyl-N'-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4-pyrimidinyl]-2-thiazolyl]- | [Molecular Formula]
C23H23N7O2S | [MDL Number]
MFCD24387531 | [MOL File]
905298-84-2.mol | [Molecular Weight]
461.54 |
| Hazard Information | Back Directory | [Uses]
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2]. | [IC 50]
LIMK1: 7.25 (pIC50); LIMK2: 6.87 (pIC50) | [References]
[1] Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. DOI:10.1021/acs.jmedchem.2c00751
[2] Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. DOI:10.1158/1535-7163.MCT-08-0826 |
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