| Identification | Back Directory | [Name]
Spiro[6H-1,3-oxazine-6,8'(9'H)-[3H,7H]pyrimido[1,6,5-gh]pyrrolo[1,2-c]purine]-2,3'(3H)-dione, 5',11'-diamino-1',2',3'a,4,5,12'a-hexahydro-2',3,9',9'-tetrahydroxy-4-[(1S)-1-(hydroxymethyl)-2-(sulfooxy)ethyl]-, (3'aS,4R,6R,9'aS,12'aS)- | [CAS]
9061-57-8 | [Synonyms]
Atelopidtoxin
Spiro[6H-1,3-oxazine-6,8'(9'H)-[3H,7H]pyrimido[1,6,5-gh]pyrrolo[1,2-c]purine]-2,3'(3H)-dione, 5',11'-diamino-1',2',3'a,4,5,12'a-hexahydro-2',3,9',9'-tetrahydroxy-4-[(1S)-1-(hydroxymethyl)-2-(sulfooxy)ethyl]-, (3'aS,4R,6R,9'aS,12'aS)- | [Molecular Formula]
C16H24N8O12S | [MOL File]
9061-57-8.mol | [Molecular Weight]
552.47 |
| Hazard Information | Back Directory | [Uses]
Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel[1][2]. | [References]
[1] Yotsu-Yamashita M, et al. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4346-51. DOI:10.1073/pnas.0400368101
[2] Shindelman J, et al., Atelopidtoxin from the Panamanian frog, Atelopus zeteki. Toxicon. 1969 Dec;7(4):315-9. DOI:10.1016/0041-0101(69)90031-2 |
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