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Melatonin-d3 is a deuterium-labeled stable isotopic analogue of the main pineal gland hormone, used as standards in NMR spectroscopy and mass spectrometry.

Melatonin takes part in the regulation of sleep, the activity of the endocrine system, circulatory and immune systems, and its pronounced antioxidant effect is also known. Replacing hydrogen atoms with its stable isotope, deuterium, allows absorption, distribution and metabolism to be determined in in vivo experiments [1]. The use of melatonin-d3 as a standard for mass spectrometry made it possible to accurately determine the melatonin content in biological fluids, such as blood plasma [2], urine [1], breast milk [3].