| Identification | Back Directory | [Name]
HD2 | [CAS]
9076-57-7 | [Synonyms]
HD2
HDAC
YY1BP
HDAC (RAT)
HISTONE DEACETYLASE
HDAC 2 His tag human
HDAC2 FLAG tag human
YY1-associated factor 1
HISTONE DEACETYLASE HD2
HISTONE DEACETYLASE (RAT)
HDAC Substrate 1, fluorogenic
HDAC Substrate 3, fluorogenic
HDAC Substrate 2, fluorogenic
HISTONE DEACETYLASE, RAT LIVER
HDAC Class 2a Substrate, fluorogenic
Transcriptional regulator homolog RPD3
HDAC Class 2a Substrate 2, fluorogenic
YY1 transcription factor binding protein
Anti-HDAC2, C-Terminal antibody produced in rabbit | [MDL Number]
MFCD03457077 |
| Hazard Information | Back Directory | [Uses]
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | [Biological Activity]
Histone deacetylase 2 (HDAC2) is known to regulate DNA damage signallingmaintain genomic stability and prevents tumor formation and progression. Hdac2 does not possess a DNA binding domainit forms multi-component repressor complexes for its interaction with transcription factors. Hdac2 also mediates cell proliferationdifferentiation and apoptosis. HDAC2 controls response to chronic inflammation in COPD (chronic obstructive pulmonary disease). It activates Wnt signaling pathway via β-catenin T-cell transcription factor. Deletion of HDAC2 along with HDAC1 leads to anemia and thrombocytopenia. |
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