Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage[1].
| Animal Model: | Male Sprague-Dawley rats (n=179; 270-300g)[1] |
| Dosage: | 25 or 50 mg/kg (in a volume of 2.0 ml/kg) |
| Administration: | SC, single dosage |
| Result: | Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity. |