| Identification | Back Directory | [Name]
Acetamide, N-[4-[4-(4-fluorophenyl)-1-methyl-2-(methylsulfinyl)-1H-imidazol-5-yl]-2-pyridinyl]- | [CAS]
908380-97-2 | [Synonyms]
CBS3595
CBS-3595
CBS 3595
Acetamide, N-[4-[4-(4-fluorophenyl)-1-methyl-2-(methylsulfinyl)-1H-imidazol-5-yl]-2-pyridinyl]- | [Molecular Formula]
C18H17FN4O2S | [MOL File]
908380-97-2.mol | [Molecular Weight]
372.42 |
| Hazard Information | Back Directory | [Uses]
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases[1]. | [References]
[1] Koch DA, et al. Efficacy and gastrointestinal tolerability of ML3403, a selective inhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats. Rheumatology (Oxford). 2014 Mar;53(3):425-32. DOI:10.1093/rheumatology/ket369 |
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