| Identification | Back Directory | [Name]
Inflachromene | [CAS]
908568-01-4 | [Synonyms]
Inflachromene
Inflachromene
(ICM)
5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione | [Molecular Formula]
C21H19N3O4 | [MDL Number]
MFCD30719253 | [MOL File]
908568-01-4.mol | [Molecular Weight]
377.39 |
| Chemical Properties | Back Directory | [Boiling point ]
532.6±60.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);79.49(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);79.49(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);6.62(Max Conc. mM) | [form ]
A crystalline solid | [pka]
9.65±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Inflachromene is a novel microglial inhibitor, which binds to HMGB1 (High Mobility Group Box 1) and HMGB2 (High mobility Group Box 2) inhibiting microglia-mediated neuroinflammation. | [in vivo]
Inflachromene (2-10 mg/kg; i.p. once daily for 4 days) effectively blocks LPS-mediated microglial activation[2].
Inflachromene (10 mg/kg; i.p. once daily for 30 days) significantly reduces the progression of disease, as determined by EAE clinical score[2].
Inflachromene (1 mg/kg; i.v.) exhibits long half-life (14.1±6.43 h) and moderate Vss (2.02±1.02 L/kg)[1].
Inflachromene (1 mg/kg; p.o.) exhibits high oral bioavailability (94%) and Cmax (0.59±0.16 g/mL)[1]. | Animal Model: | Male C57BL/6 mice (11 weeks; 25-30 g) are treated with LPS[2] | | Dosage: | 2, 10 mg/kg | | Administration: | I.p. once daily for 4 days | | Result: | Blocked LPS-mediated microglial activation, even at a dose of 2 mg/kg. |
| Animal Model: | Sprague-Dawley (SD) rats (7 weeks; 230-250 g)[1] | | Dosage: | 1 mg/kg (Pharmacokinetic Analysis) | | Administration: | I.v. and p.o. administration | | Result: | I.v.: t1/2=14.1±6.43 h; CL= 0.14±0.01 L/kg/h; Vss=2.02±1.02 L/kg.
P.o.: t1/2=7.96±1.16 h; F=94%; Cmax=0.59±0.16 g/mL.
|
|
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|