ChemicalBook--->CAS DataBase List--->90924-46-2

90924-46-2

90924-46-2 Structure

90924-46-2 Structure
IdentificationBack Directory
[Name]

Methyl 2-oxindole-4-carboxylate
[CAS]

90924-46-2
[Synonyms]

Nintedanib Impurity 129
4-Methoxycarbonyl-2-oxindole
Methyl 2-oxindole-4-carbo...
METHYL OXINDOLE-4-CARBOXYLATE
METHYL 2-OXINDOLE-4-CARBOXYLATE
Methyl-2-Dxoindline-4-carboxylate
Methyl 2-oxoindoline-4-carboxylate
methyl 2-oxo-2,3-dihydro-1H-indole-4-carboxylate
Methyl 2-oxindole-4-carboxylate in stock Factory
4-Indolinecarboxylicacid, 2-oxo-, methyl ester (7CI)
2-oxo-1,3-dihydroindole-4-carboxylic acid methyl ester
1H-Indole-4-carboxylic acid, 2,3-dihydro-2-oxo-, Methyl ester
[EINECS(EC#)]

2017-001-1
[Molecular Formula]

C10H9NO3
[MDL Number]

MFCD08277245
[MOL File]

90924-46-2.mol
[Molecular Weight]

191.18
Chemical PropertiesBack Directory
[storage temp. ]

Store at 0-8 °C
[Appearance]

yellow solid
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2933998090
Spectrum DetailBack Directory
[Spectrum Detail]

Methyl 2-oxindole-4-carboxylate(90924-46-2)1HNMR
Hazard InformationBack Directory
[Synthesis]

Benzeneacetic acid, 2-(methoxycarbonyl)-6-nitro-, methyl ester

93534-73-7

Methyl 2-oxindole-4-carboxylate

90924-46-2

General method: Compound 22 (15.8 mmol) or Compound 23 (15.8 mmol) was dissolved in methanol, 10 μl of 10% Pd-C catalyst was added and hydrogen was passed through. The reaction mixture was stirred for 5 hours. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The residue obtained was purified by recrystallization from methanol to give methyl 4-carboxylate dihydroindol-2-one.

[References]

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4557 - 4561
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