ChemicalBook--->CAS DataBase List--->909395-70-6

909395-70-6

909395-70-6 Structure

909395-70-6 Structure
IdentificationBack Directory
[Name]

Romosozumab
[CAS]

909395-70-6
[Synonyms]

AMG785
AMG-785
CDP7851
AMG 785
CDP-7851
CDP 7851
Romosozumab
Research Grade Romosozumab(DHJ48701)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Romosozumab is a humanized monoclonal anti-sclerostin antibody, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis[1][2].
[in vivo]

Romosozumab (30 mg/kg; s.c. twice a week for 10 weeks) converts trabecular rods into trabecular plates in cynomolgus monkeys[1]. Romosozumab (3 and 30 mg/kg; s.c. once a week for 6 or 12 months) improves bone mass, architecture, and bone strength, and maintains bone quality at the same time in mature cynomolgus monkeys with 4 months post-ovariectomy[2].

Animal Model:Male cynomolgus monkeys[1]
Dosage:30 mg/kg
Administration:Subcutaneous injection; 30 mg/kg twice a week for 10 weeks
Result:Increased bone formation and plate-like trabecular morphology, and improved mechanical performance.
[References]

[1] Paik J, Scott LJ. Romosozumab: A Review in Postmenopausal Osteoporosis. Drugs Aging. 2020 Nov;37(11):845-855. DOI:10.1007/s40266-020-00793-8
[2] Ominsky MS, et al. Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys. J Bone Miner Res. 2017 Apr;32(4):788-801. DOI:10.1002/jbmr.3036
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