| Hazard Information | Back Directory | [Description]
GSK494581A is a both a glycine transporter subtype 1 inhibitor and GPR55 agonist. | [Uses]
GSK494581A is a specific ligand for human GPR55 (pEC50 of 6.8) and also acts as an inhibitor of glycine transporter subtype 1 (GlyT1). GSK494581A may regulate pain signaling, bone morphogenesis, and vascular endothelial cell formation by binding to GPR55[1]. | [IC 50]
rGlyT1 | [References]
[1] Brown AJ, et al. Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther. 2011 Apr;337(1):236-46. DOI:10.1124/jpet.110.172650 |
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