| Identification | Back Directory | [Name]
Tert-butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate | [CAS]
909422-39-5 | [Synonyms]
Tert-butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate
1-Piperidinecarboxylic acid, 4-[3-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H25NO3 | [MDL Number]
MFCD30099260 | [MOL File]
909422-39-5.mol | [Molecular Weight]
291.39 |
| Chemical Properties | Back Directory | [Boiling point ]
426.0±40.0 °C(Predicted) | [density ]
1.109±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
14.36±0.10(Predicted) | [InChIKey]
OWDXAWCQYCRTIR-UHFFFAOYSA-N | [SMILES]
O=C(N(CC1)CCC1C2=CC(CO)=CC=C2)OC(C)(C)C |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1 |
| Hazard Information | Back Directory | [Uses]
tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. | [reaction suitability]
reagent type: linker |
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