| Identification | Back Directory | [Name]
3(2H)-Pyridazinone, 4,5-dihydro-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl- | [CAS]
909719-71-7 | [Synonyms]
KCA1490
KCA-1490
KCA 1490
3(2H)-Pyridazinone, 4,5-dihydro-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl- | [Molecular Formula]
C14H13F3N4O2 | [MOL File]
909719-71-7.mol | [Molecular Weight]
326.27 |
| Hazard Information | Back Directory | [Description]
KCA-1490 is a dual PDE3/4 inhibitor. | [Uses]
KCA-1490 is a dual PDE3/4 inhibitor with IC50 values of 369 nM and 42 nM, respectively. KCA-1490 exhibits potent bronchodilatory and anti-inflammatory activity. KCA-1490 suppresses Histamine (HY-B1204)-induced bronchoconstriction in vivo, which is promising for research of asthma and chronic obstructive pulmonary disease (COPD)[1][2][3]. | [References]
[1] Ochiai K, et al. Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5833-8. DOI:10.1016/j.bmcl.2012.07.088
[2] Ochiai K, et al. Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration. Bioorg Med Chem Lett. 2013 Jan 1;23(1):375-81. DOI:10.1016/j.bmcl.2012.08.121
[3] Jin J, et al. PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes. Int J Mol Sci. 2023 Jul 15;24(14):11518. DOI:10.3390/ijms241411518 |
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