| Identification | Back Directory | [Name]
PQ 69 | [CAS]
910045-32-8 | [Synonyms]
PQ 69
4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one | [Molecular Formula]
C20H19FN4O | [MDL Number]
MFCD30182281 | [MOL File]
910045-32-8.mol | [Molecular Weight]
350.39 |
| Hazard Information | Back Directory | [Description]
PQ-69 is a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 exhibits potent antagonist effects on A1AR in vitro, ex vivo and in vivo. | [Uses]
PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208?nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction[1]. | [References]
[1] Min Lu, et al. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 2014 Dec;10(4):619-29. DOI:10.1007/s11302-014-9424-5 |
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