| Identification | Back Directory | [Name]
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide | [CAS]
910634-41-2 | [Synonyms]
KF 89617
Litronesib
LY 2523355
LY-2523355; KF-89617
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (5R)- | [Molecular Formula]
C23H37N5O4S2 | [MOL File]
910634-41-2.mol | [Molecular Weight]
511.7 |
| Chemical Properties | Back Directory | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 50 mg/mL (97.71 mM) | [form ]
Solid | [pka]
9.47±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Litronesib is a selective allosteric kinesin Eg5 inhibitor in patients with advanced cancer. | [in vivo]
Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1]. | [IC 50]
Eg5 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|