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910634-41-2

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910634-41-2 Structure

910634-41-2 Structure
IdentificationBack Directory
[Name]

(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
[CAS]

910634-41-2
[Synonyms]

KF 89617
Litronesib
LY 2523355
LY-2523355; KF-89617
(-)-N-[4-(2,2-Dimethylpropanoyl)-5-[[2-(ethylamino)ethanesulfonamido]methyl]-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-, (5R)-
[Molecular Formula]

C23H37N5O4S2
[MOL File]

910634-41-2.mol
[Molecular Weight]

511.7
Chemical PropertiesBack Directory
[density ]

1.23±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 50 mg/mL (97.71 mM)
[form ]

Solid
[pka]

9.47±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Litronesib is a selective allosteric kinesin Eg5 inhibitor in patients with advanced cancer.
[in vivo]

Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].

[IC 50]

Eg5
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