| Identification | Back Directory | [Name]
Adapalene (sodiuM salt) | [CAS]
911110-93-5 | [Synonyms]
CD 271 sodium salt
Adapalene (sodiuM salt) | [Molecular Formula]
C28H28NaO3* | [MDL Number]
MFCD28168032 | [MOL File]
911110-93-5.mol | [Molecular Weight]
435.51 |
| Hazard Information | Back Directory | [Uses]
Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity[1][2][3]. | [in vivo]
Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice[3]. | Animal Model: | Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells[3] | | Dosage: | 15, 20, 65, 100 mg/kg | | Administration: | P.o. daily for 21 days | | Result: | Significantly reduced tumor weight and volume.
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| [References]
[1] Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103. DOI:10.1016/s0190-9622(97)70050-1
[2] Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315. DOI:10.1016/j.bioorg.2019.103315
[3] Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8. DOI:10.3892/mmr.2015.4310 |
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