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(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(?)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine is a potent CDK inhibitor, with IC50 values of 0.03 and 0.05 μM for CDK1 and CDK5, respectively[1]. | [References]
[1] Nguyen TB, et al. Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. J Med Chem. 2012 Mar 22;55(6):2811-9. DOI:10.1021/jm201727w |
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