| Identification | Back Directory | [Name]
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- | [CAS]
911715-90-7 | [Synonyms]
AZD 8797
AZD 8797; AZD-8797
CX3CR1 antagonist 18a
(R)-2-(2-AMINO-5-((S)-1-PHENYLETHYLTHIO)THIAZOLO[4,5-D]PYRIMIDIN-7-YLAMINO)-4-
METHYLPENTAN-1-OL
1-Pentanol, 2-[[2-aMino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyriMidin-7-yl]aMino]-4-Methyl-, (2R)- | [Molecular Formula]
C19H25N5OS2 | [MDL Number]
MFCD28139065 | [MOL File]
911715-90-7.mol | [Molecular Weight]
403.56 |
| Chemical Properties | Back Directory | [Boiling point ]
651.1±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 150 mg/mL (371.69 mM) | [form ]
Solid | [pka]
14.47±0.10(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
ZMQSLMZOWVGBSM-GXTWGEPZSA-N | [SMILES]
C(O)[C@H](NC1N=C(S[C@H](C2=CC=CC=C2)C)N=C2N=C(N)SC2=1)CC(C)C |
| Hazard Information | Back Directory | [Uses]
(2R)-2-[[2-Amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol is an allosteric non-competitive modulator of the human CX3CR1 receptor. It can be used to develop treatment for multiple sclerosis. | [in vivo]
AZD8797 treatment in Dark Agouti rats with myelin oligodendrocyte glycoprotein-induced EAE results in reduced paralysis, CNS pathology, and incidence of relapses. The compound is effective when starting treatment before onset, as well as after the acute phase[2]. | [IC 50]
CX3CR1: 3.9 nM (Ki, 125I-CX3CL-CX3CR1 in HEK293S cells); 125I-IL-8-CXCR2: 2800 nM (Ki, in HEK293S cells) |
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| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|