| Identification | Back Directory | [Name]
AMG-1 | [CAS]
913376-84-8 | [Synonyms]
AMG-1
AMG1;AMG 1
N-[3-Fluoro-4-[(7-Methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-Methylpropyl)-5-Methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaMide
1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl- | [Molecular Formula]
C31H29FN4O5 | [MDL Number]
MFCD22631502 | [MOL File]
913376-84-8.mol | [Molecular Weight]
556.58 |
| Hazard Information | Back Directory | [Uses]
AMG-1 is a potent inhibitor of human c-Met and RON. | [Definition]
ChEBI: N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-4-pyrazolecarboxamide is an aromatic amide. | [in vivo]
SYN1143 (10-100 mg/kg; p.o. for 22 d) inhibits the growth of c-Met-dependent and constitutively active RON-expressing tumors in mice[1].
SYN1143 (20-50 μg; transferred into calvarial defects) stimulates bone formation in critical-sized defects of mouse calvarial bone[2]. | Animal Model: | Female CD1 nu/nu mice (6-8 weeks) bearing NIH3T3 TPR-Met s.c. tumors[1] | | Dosage: | 10, 30, 100 mg/kg | | Administration: | Oral gavage either once or twice daily for 22 days | | Result: | Significantly inhibited tumor growth at doses of 30 or 100 mg/kg once daily or at 30 mg/kg twice daily.
Completely inhibited tumor growth at a dose of 100 mg/kg once daily.
Did not adversely affect body weight.
|
| [IC 50]
RON: 9 nM (IC50) | [storage]
Store at -20°C |
|
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BOC Sciences
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Lynnchem
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Novachemistry
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