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913541-47-6

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913541-47-6 Structure

913541-47-6 Structure
IdentificationBack Directory
[Name]

SLx-4090
[CAS]

913541-47-6
[Synonyms]

KD-026
SLx-4090
KD-026 913541-47-6
KD 026,microsomal triglyceride transfer protein,MTP inhibitor,inhibit,Inhibitor,enterocytic-specific,dyslipidemia
2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-[[[6-methoxy-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-, phenyl ester
[Molecular Formula]

C31H25F3N2O4
[MDL Number]

MFCD28502203
[MOL File]

913541-47-6.mol
[Molecular Weight]

546.54
Chemical PropertiesBack Directory
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO: Sparingly soluble: 1-10 mg/mL
Ethanol: Slightly soluble: 0.1-1 mg/mL
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia[1].
[in vivo]

SLX-4090 (orally, 30 mg/kg) reduces postprandial lipids by 50% with an ED50 value 7 mg/kg in rats[1].

[References]

[1] Enoch Kim, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85. DOI:10.1124/jpet.110.177527
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