| Identification | Back Directory | [Name]
Esuprone | [CAS]
91406-11-0 | [Synonyms]
LU43839
LU-43839
Esuprone
LU 43839
3,4-dimethyl-2-oxo-2H-1-benzopyran-7-yl ethanesulfonate | [Molecular Formula]
C13H14O5S | [MDL Number]
MFCD00865350 | [MOL File]
91406-11-0.mol | [Molecular Weight]
282.315 |
| Hazard Information | Back Directory | [Uses]
Esuprone is a brain-penetrant, orally active and selective MAO A inhibitor with an IC50 of 7.3 nM. Esuprone can be used for neurological research[1][2]. | [in vivo]
Esuprone (20 mg/kg, p.o., 2 h) significantly increased afterdischarge threshold (ADT) in rats by 130% above control[1].
| [IC 50]
MAO-A: 7.3 nM (IC50) | [References]
[1] L?scher W, et al. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288(3):984-92. PMID:10027835
[2] Bergstr?m M, et al. MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8. DOI:10.1007/s002280050260 |
|
|