| Identification | Back Directory | [Name]
7'-OH-N-trityl Morpholino thyMine | [CAS]
914361-76-5 | [Synonyms]
PMO-T Precusor
Morpholino-5-Me-U
PMO Thymidine Precusor
7'-OH-N-trityl Morpholino thyMine
7'-Hydroxy-N-tritylmorpholino thymine monomer
1-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2, 4(1H, 3H)-dione
1-((2R,6S)-6-(hydroxyMethyl)-4-tritylMorpholin-
2-yl)-5-MethylpyriMidine-2,4-(1H,3H)-dione
1-[(2R,6S)-6-(Hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | [Molecular Formula]
C29H29N3O4 | [MDL Number]
MFCD22666300 | [MOL File]
914361-76-5.mol | [Molecular Weight]
483.56 |
| Chemical Properties | Back Directory | [density ]
1.259±0.06 g/cm3(Predicted) | [pka]
9.51±0.10(Predicted) | [InChIKey]
SINOYLIIFJJPCM-IZZNHLLZSA-N | [SMILES]
C1(=O)N([C@@H]2O[C@H](CO)CN(C(C3=CC=CC=C3)(C3=CC=CC=C3)C3=CC=CC=C3)C2)C=C(C)C(=O)N1 |
| Hazard Information | Back Directory | [Description]
7'-OH-N-trityl Morpholino thyMine (PMO Thymidine Precusor) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibiting DNA synthesis, induction of apoptosis, etc.
| [Uses]
7’-OH-N-trityl morpholinothymine (PMO Thymidine Precusor) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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