| Identification | Back Directory | [Name]
SMP-028 | [CAS]
914389-14-3 | [Synonyms]
SMP-028
Urea, N-[2-[2-[(3-fluorophenyl)imino]-4-[4-(4-morpholinyl)phenyl]-3(2H)-thiazolyl]ethyl]-N'-methyl- | [Molecular Formula]
C23H26FN5O2S | [MDL Number]
MFCD29036689 | [MOL File]
914389-14-3.mol | [Molecular Weight]
455.55 |
| Hazard Information | Back Directory | [Uses]
SMP-028 is an inhibitor of neutral cholesterol esterase (CEase), with an IC50 of 1.01 μM. | [References]
[1] Nishizato Y, et al. Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028--for human safety in clinical study. Toxicol Appl Pharmacol. 2014 May 1;276(3):213-9. DOI:10.1016/j.taap.2014.02.016
[2] Nishizato Y, et al. Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats. Toxicol In Vitro. 2014 Apr;28(3):397-402. DOI:10.1016/j.tiv.2013.12.005 |
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