| Identification | Back Directory | [Name]
4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile | [CAS]
915086-32-7 | [Synonyms]
915086-32-7
Thiohydantoin androgen receptor antagonist
4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile
Benzonitrile, 4-[3-(4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-
4-[3-(4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile | [Molecular Formula]
C19H14F3N3O2S | [MDL Number]
MFCD28978634 | [MOL File]
915086-32-7.mol | [Molecular Weight]
405.39 |
| Chemical Properties | Back Directory | [Boiling point ]
548.7±60.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
Solid | [pka]
9.01±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Androgen receptor antagonist 9 (compound 28) is an antagonist of the androgen receptor[1]. | [References]
[1] Jung ME, et al. Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC). J Med Chem. 2010 Apr 8;53(7):2779-96. DOI:10.1021/jm901488g |
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