| Identification | Back Directory | [Name]
amphethinile | [CAS]
91531-98-5 | [Synonyms]
CRC 82-07
Amphetinile
amphethinile
1H-Indole-3-carbonitrile, 2-amino-5-(phenylthio)- | [Molecular Formula]
C15H11N3S | [MDL Number]
MFCD09838112 | [MOL File]
91531-98-5.mol | [Molecular Weight]
265.33 |
| Hazard Information | Back Directory | [Uses]
Amphethinile is an anti-tubulin agent. The affinity constant for the association (Ka) of Amphethinile with tubulin is 1.3 μM. | [in vivo]
Pharmacokinetic studies in male mice are undertaken. Area under the curve values (AUC), show that levels of 313 μg/L per hour are attained at doses equivalent to the LD10. The alpha half life is 8 min after a bolus intravenous injection. The beta half life is 100 min and relatively independent of dose level[2]. | [storage]
Store at -20°C | [References]
[1] McGown AT, et al. Interaction of the novel agent amphethinile with tubulin. Br J Cancer. 1989 Jun;59(6):865-8. DOI:10.1038/bjc.1989.183
[2] McGown AT, et al. Pre-clinical studies of a novel anti-mitotic agent, amphethinile. Br J Cancer. 1988 Feb;57(2):157-9. DOI:10.1038/bjc.1988.32 |
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