| Identification | Back Directory | [Name]
Naveglitazar (racemate) | [CAS]
916085-47-7 | [Synonyms]
Naveglitazar (racemate)
Benzenepropanoic acid, α-methoxy-4-[3-(4-phenoxyphenoxy)propoxy]- | [Molecular Formula]
C25H26O6 | [MDL Number]
MFCD17166972 | [MOL File]
916085-47-7.mol | [Molecular Weight]
422.47 |
| Chemical Properties | Back Directory | [Boiling point ]
587.3±50.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
3.54±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Naveglitazar racemate (LY519818 racemate) is the racemate of Naveglitazar. Naveglitazar is a nonthiozolidinedione peroxisome proliferator-activated receptor (PPAR) α-γ dual, γ-dominant agonist that has shown glucose-lowering potential in animal models[1]. | [in vivo]
[14C]Naveglitazar is quickly absorbed and moderately metabolized before elimination. After oral administration, 47, 31, and 62% of the radioactivity, as assessed by AUC values, are circulating as metabolites in mice, rats, and monkeys, respectively. Half-lives for Naveglitazar and radioactivity are similar within each species; however, monkeys have substantially longer half-lives in comparison to mice and rats. Naveglitazar and radioactivity are slowly cleared from the system circulation in all species evaluated[1]. | [storage]
Store at -20°C | [References]
[1] Yi P, et al. The disposition and metabolism of naveglitazar, a peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist in mice, rats, and monkeys. Drug Metab Dispos. 2007 Jan;35(1):51-61. DOI:10.1124/dmd.106.012328 |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|