| Identification | Back Directory | [Name]
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine | [CAS]
916603-07-1 | [Synonyms]
CZC-8004
CZC 00008004
DianilinopyriMidine_01
N-(4-broMophenyl)-N-(naphthalen-2-yl)
N-(4-broMophenyl)-N-(naphthalen-2-yl) naphthalen-1-aMine
Target-5 (Kinase Probe Tool, APM-1)/Dianilinopyrimidine_01
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-pyrimidinediamine
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
2,4-Pyrimidinediamine, N2-[4-(aminomethyl)phenyl]-5-fluoro-N4-phenyl- | [Molecular Formula]
C17H16FN5 | [MDL Number]
MFCD16251195 | [MOL File]
916603-07-1.mol | [Molecular Weight]
309.34 |
| Chemical Properties | Back Directory | [Boiling point ]
514.1±60.0 °C(Predicted) | [density ]
1.332 | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming) | [form ]
solid | [pka]
9.14±0.10(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
CZC-8004 (916603-07-1) is a pan-specific kinase inhibitor. May be coupled to sepharose via its amino-side chain for affinity chromatography applications1. | [Uses]
A novel enzyme-interacting compounds using immobilized broad-spectrum ligands | [Uses]
CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes. | [Definition]
ChEBI: CZC8004 is an aminopyrimidine and an organofluorine compound. It has a role as a protein kinase inhibitor. | [storage]
Store at -20°C | [References]
1) Klutchko?et al. (1998),?2-Substituted aminopyrido[2,3-d]pyrilidin-7(8H)-ones, structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity; J. Med. Chem.,?41?3276 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
|