| Identification | Back Directory | [Name]
MEPHETYL TETRAZOLE | [CAS]
916923-10-9 | [Synonyms]
MEPHETYL TETRAZOLE
1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
1H-Tetrazole, 1-[2-(4-methoxyphenyl)ethyl]-5-[1-(4-methylphenyl)cyclopropyl]- | [Molecular Formula]
C20H22N4O | [MDL Number]
MFCD11045297 | [MOL File]
916923-10-9.mol | [Molecular Weight]
334.41 |
| Chemical Properties | Back Directory | [Boiling point ]
558.4±39.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
oil | [pka]
1.11±0.10(Predicted) | [color ]
pale yellow | [InChI]
1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3 | [InChIKey]
VREPWWBWXVLSEF-UHFFFAOYSA-N | [SMILES]
COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1 |
| Hazard Information | Back Directory | [Uses]
Mephetyl tetrazole is a potassium channel Kv1.5 blocker, with an IC50 of 330 nM. Mephetyl tetrazole can be used for the research of cancer[1]. | [Biological Activity]
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP)but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation. | [References]
[1] Felipe A, et al. Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention. Curr Med Chem. 2012;19(5):661-74. DOI:10.2174/092986712798992048 |
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