| Chemical Properties | Back Directory | [Melting point ]
>233 °C (decomp) | [Boiling point ]
506.8±50.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol:1.0(Max Conc. mg/mL);3.29(Max Conc. mM) | [form ]
A solid | [pka]
7.17±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
Globosuxanthone A is a fungal metabolite originally isolated from C. globosum. It is cytotoxic to various human solid tumor cell lines, including MCF-7, PC3, LNCap, and DU145 cells (IC50s = 1.3, 0.65, 1.5, and 1.2 μM, respectively). It induces accumulation of cells in the G2/M and S phases of the cell cycle in NCI-H460 and PC3M cells. Globosuxanthone A is also active against C. albicans but not S. aureus, E. coli, or M. hiemalis. | [Uses]
Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2]. | [storage]
Store at -20°C | [References]
[1] Miao C, et al. Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol (Praha). 2020;65(3):567-572. DOI:10.1007/s12223-019-00762-8
[2] Wijeratne EM, et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem. 2006;14(23):7917-7923. DOI:10.1016/j.bmc.2006.07.048 |
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