| Identification | Back Directory | [Name]
fibrostatin C | [CAS]
91776-47-5 | [Synonyms]
P-23924C
fibrostatin C
N-Acetyl-S-[(5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methyl]-L-cysteine | [Molecular Formula]
C18H19NO8S | [MDL Number]
MFCD01735899 | [MOL File]
91776-47-5.mol | [Molecular Weight]
409.413 |
| Hazard Information | Back Directory | [Description]
Fibrostatin C is a prolyl 4-hydroxylase (PH) inhibitor produced by Streptomyces catenulae subsp. griseospora. | [Uses]
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery[1][2]. | [References]
[1] Ishimaru T, et al. Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. J Antibiot (Tokyo). 1988 Nov;41(11):1668-74. DOI:10.7164/antibiotics.41.1668
[2] Saika S, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234 Suppl 1:S214-22. DOI:10.1007/BF02343075 |
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