| Identification | Back Directory | [Name]
9-(3-hydroxyphenyl)-8-phenyl-4,9-dihydrotetraazolo[1',5':1,2]pyrimido[4,5-d]pyridazin-5-ol | [CAS]
919010-22-3 | [Synonyms]
Pfn1INC2
Pfn1-IN-C2
Pfn1 IN C2
Pfn1 inhibitor C2
9-(3-hydroxyphenyl)-8-phenyl-4,9-dihydrotetraazolo[1',5':1,2]pyrimido[4,5-d]pyridazin-5-ol | [Molecular Formula]
C18H13N7O2 | [MOL File]
919010-22-3.mol | [Molecular Weight]
359.34 |
| Hazard Information | Back Directory | [Description]
Pfn1-IN-C2 is an inhibitor of Profilin1 (Pfn1). It has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo. | [Uses]
Pfn1-IN-2 is an inhibitor of Profilin1 (Pfn1) and has the activity to interfere with the interaction between Pfn1 and actin. Pfn1-IN-2 can significantly reduce the overall level of intracellular filamentous (F) actin. Pfn1-IN-2 also slows down the migration and proliferation of endothelial cells (EC). Pfn1-IN-2 can inhibit the angiogenic ability of endothelial cells both in vivo and in vitro[1]. | [References]
[1] Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction |
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