| Identification | Back Directory | [Name]
DIPHTHERIA TOXIN | [CAS]
92092-36-9 | [Synonyms]
DIPHTHERIA TOXIN
Diphtheria toxin (CRM197)
DIPHTHERIA TOXIN, CRM MUTANT
CORYNEBACTERIUM DIPHTHERIAE TOXIN
(GLU-52)-DIPHTHERIA TOXIN FROM*CORYNEBAC
(glu52)-diphtheria toxin from*corynebacterium dip
Diphtheria toxin[Glu-52], Corynebacterium diphtheriae
Diphtheria Toxin from Corynebacterium diphtheriae
DIPHTHERIA TOXIN, UNNICKED, CORYNEBACTERIUM DIPHTHERIAE
[glu52]-diphtheria toxin from corynebacterium diphtheriae | [MDL Number]
MFCD00163490 |
| Hazard Information | Back Directory | [Uses]
Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell specific cytotoxicity. The translocation domain of bacterial toxins with natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy. | [Uses]
Diphtheria Toxin, CRM Mutant is an agent that does not have NAD:EF2 ADP-ribosyltransferase activity. | [Biochem/physiol Actions]
Inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II. | [References]
[1] LADOKHIN A S. pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.[J]. Toxins, 2013, 5 8: 1362-1380. DOI: 10.3390/toxins5081362
[2] MURPHY J R. Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process.[J]. Toxins, 2011, 3 3: 294-308. DOI: 10.3390/toxins3030294
[3] MAREIKE BÜTEPAGE. Intracellular Mono-ADP-Ribosylation in Signaling and Disease.[J]. Cells, 2015, 4 4: 569-595. DOI: 10.3390/cells4040569 |
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