| Identification | Back Directory | [Name]
3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one | [CAS]
921099-13-0 | [Synonyms]
3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one, 3-(3,4-dimethoxyphenyl)-7-[2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy]-4-methyl- | [Molecular Formula]
C26H32N2O6 | [MOL File]
921099-13-0.mol | [Molecular Weight]
468.54 |
| Chemical Properties | Back Directory | [Boiling point ]
659.5±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.96±0.10(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation[1]. | [References]
[1] Fang A, et al. Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5450-5453. DOI:10.1016/j.bmcl.2017.10.073 |
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