| Identification | Back Directory | [Name]
BL5923 | [CAS]
921208-19-7 | [Synonyms]
BL5923
Acetamide, N-[5-chloro-2-[3-[9-[(4-fluorophenyl)methyl]-3-oxa-7,9-diazabicyclo[3.3.1]non-7-yl]-3-oxo-1-propen-1-yl]-4-methoxyphenyl]- | [Molecular Formula]
C25H27ClFN3O4 | [MOL File]
921208-19-7.mol | [Molecular Weight]
487.95 |
| Hazard Information | Back Directory | [Uses]
CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC50 of 0.009 μM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model[1]. | [IC 50]
CCR1: 3 nM (IC50) | [References]
[1] Revesz L, et al. Bridged piperazines and piperidines as CCR1 antagonists with oral activity in models of arthritis and multiple sclerosis[J]. Letters in Drug Design & Discovery, 2006, 3(10): 689-694. |
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