| Identification | Back Directory | [Name]
P53R3 | [CAS]
922150-12-7 | [Synonyms]
P53R3
P53R3,P-53R3
Ensartinib HCl
L-Valine, N-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-, methyl ester | [Molecular Formula]
C32H35Cl2N5O2 | [MOL File]
922150-12-7.mol | [Molecular Weight]
592.56 |
| Hazard Information | Back Directory | [Uses]
P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research[1]. | [storage]
4°C, stored under nitrogen | [References]
[1] Alejandro Parrales, et al. Targeting Oncogenic Mutant p53 for Cancer Therapy. Front Oncol DOI:10.3389/fonc.2015.00288 |
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