| Identification | Back Directory | [Name]
Benzamide, 3-bromo-N-[4-(7-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]- | [CAS]
923140-39-0 | [Synonyms]
SARS-CoV-2 nsp13-IN-4
Benzamide, 3-bromo-N-[4-(7-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]- | [Molecular Formula]
C20H15BrN4O | [MOL File]
923140-39-0.mol | [Molecular Weight]
407.26 |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective nsp13 helicase small-molecule inhibitor and inhibit the ssDNA+ ATPase activity of nsp13 with an IC50 value of 57 μM. SARS-CoV-2 nsp13-IN-4 is agentlike molecule with molecular weight of less than 450Da and can provide a broad-spectrum antiviral effect[1]. | [References]
[1] Aliakbar Khalili Yazdi, et al. Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. ACS Infect Dis. 2022 Jul 13. DOI:10.1021/acsinfecdis.2c00165 |
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