| Identification | Back Directory | [Name]
Imidazo[1,2-b]pyridazin-6-amine, N-propyl-3-(4-pyridinyl)- | [CAS]
923596-52-5 | [Synonyms]
Lck-IN-1
Imidazo[1,2-b]pyridazin-6-amine, N-propyl-3-(4-pyridinyl)- | [Molecular Formula]
C14H15N5 | [MDL Number]
MFCD34471141 | [MOL File]
923596-52-5.mol | [Molecular Weight]
253.3 |
| Chemical Properties | Back Directory | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
powder | [pka]
3.91±0.30(Predicted) | [color ]
white to beige | [InChIKey]
XTMROGQLIVGYKF-UHFFFAOYSA-N | [SMILES]
CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3 |
| Hazard Information | Back Directory | [Uses]
Lck-IN-1 is a potent lymphocyte protein tyrosine kinase (Lck) inhibitor extracted from patent WO2007013673A1, example 48[1]. | [Biological Activity]
ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD03259011.5μM CHIR 99021). | [storage]
Store at -20°C | [References]
[1] Kazuo Nakai, et al. Fused heterocycles as lck inhibitors. WO2007013673A1. |
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| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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