| Identification | Back Directory | [Name]
9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(PHENYLMETHOXY)IMINO]- | [CAS]
924296-18-4 | [Synonyms]
DUB-IN-1
DUBs-IN-1
USP8-IN-22d
DUBs inhibitor 1
Deubiquitinase,DUBs,Inhibitor,DUBIN1,inhibit,DUB IN 1
9-Benzyloxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
9-[(Phenylmethoxy)imino]-9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile
9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(PHENYLMETHOXY)IMINO]- | [Molecular Formula]
C20H11N5O | [MDL Number]
MFCD11977746 | [MOL File]
924296-18-4.mol | [Molecular Weight]
337.33 |
| Hazard Information | Back Directory | [Uses]
DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8[1]. | [Biological Activity]
Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.
DUB-IN-1 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 850 nM/USP8>100 μM/USP7). DUB-IN-1 inhibits the proliferation (200-800 nM for 24 or 48h; LN229U87MGand T98G cells)invasion (500-800 nM for 48 or 96h; LN229 and T98G cells)and stemness (500-800 nM for 7 or 14 days; LN229 and T98G cells) in GBM cultures. | [References]
[1] Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8. DOI:10.1002/cmdc.200900409 |
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SPIRO PHARMA
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| Tel: |
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www.spiropharma.com.cn |
| Company Name: |
Musechem
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+1-800-259-7612 |
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www.musechem.com |
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