| Identification | Back Directory | [Name]
BENOXATHIAN HCL | [CAS]
92642-97-2 | [Synonyms]
BENOXATHIAN HCL
BENOXATHIAN HYDROCHLORIDE SELECTIVE A1 A DRENORE | [Molecular Formula]
C19H23NO4S.ClH | [MDL Number]
MFCD00055188 | [MOL File]
92642-97-2.mol | [Molecular Weight]
397.921 |
| Chemical Properties | Back Directory | [Melting point ]
104-105 °C | [storage temp. ]
-20°C, away from moisture | [solubility ]
H2O: Aqueous solutions may be stored for several weeks at -20°C.soluble | [form ]
solid | [color ]
white | [Water Solubility ]
H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.)
ethanol: soluble
isopropanol: soluble | [InChI]
1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H | [InChIKey]
OWRADFDDJVNMGL-UHFFFAOYSA-N | [SMILES]
Cl.COc1cccc(OC)c1OCCNCC2CSc3ccccc3O2 |
| Hazard Information | Back Directory | [Uses]
Benoxathian hydrochloride is a potent α1 adrenoceptor antagonist, can be used for researching anorexia[1]. | [Biological Activity]
Selective α1-adrenoceptor antagonist. | [in vivo]
Benoxathian hydrochloride (10 nM; paraventricular nucleus injection) completely reverses the anorexia induced by 2.5, 5.0 or 10.0 mg/kg Phenylpropanolamine (IP) in rats[1]. | [storage]
-20°C, away from moisture | [References]
[1] Wellman PJ, et al. Reversal of phenylpropanolamine anorexia in rats by the alpha-1 receptor antagonist benoxathian. Pharmacol Biochem Behav. 1991 Apr;38(4):905-8. DOI:10.1016/0091-3057(91)90261-y |
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