| Identification | Back Directory | [Name]
CRTH2-IN-1 | [CAS]
926661-54-3 | [Synonyms]
CRTH2-IN-1
Ramatroban analog
CRTH-2-IN-1,CRTH2 IN 1,CRTH2IN1
Pyrido[1,2-a]indole-10-acetic acid, 7-[[(4-fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro- | [Molecular Formula]
C21H21FN2O4S | [MDL Number]
MFCD31619314 | [MOL File]
926661-54-3.mol | [Molecular Weight]
416.47 |
| Chemical Properties | Back Directory | [Boiling point ]
636.5±65.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.50±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50 of 6 nM in a human DP2 binding assay. | [IC 50]
CYP 2C9: 5 μM (IC50); CYP3A4: 7 μM (IC50); hDP2: 6 nM (IC50); hDP1: 1 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. DOI:10.1016/j.bmcl.2009.06.085 |
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