| Identification | Back Directory | [Name]
AP 24149 | [CAS]
926922-29-4 | [Synonyms]
AP 24149
9-[(E)-2-(2,6-dimethylphenyl)ethenyl]-N-(4-dimethylphosphorylphenyl)purin-6-amine | [Molecular Formula]
C23H24N5OP | [MOL File]
926922-29-4.mol | [Molecular Weight]
417.443 |
| Hazard Information | Back Directory | [Uses]
AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1]. | [IC 50]
Abl: 3.6 nM (IC50); Src: 9.1 nM (IC50) | [References]
[1] Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28. DOI:10.1111/j.1747-0285.2009.00905.x |
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