| Identification | Back Directory | [Name]
AAD-2004 | [CAS]
927685-43-6 | [Synonyms]
AAD-2004
Crisdesalazine
Crisdesalazine
(AAD-2004
Benzoic acid, 2-hydroxy-5-[[2-[4-(trifluoromethyl)phenyl]ethyl]amino]- | [Molecular Formula]
C16H14F3NO3 | [MDL Number]
MFCD18633186 | [MOL File]
927685-43-6.mol | [Molecular Weight]
325.28 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [Boiling point ]
496.4±45.0 °C(Predicted) | [density ]
1.410±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.31±0.10(Predicted) | [color ]
White to off-white | [Cosmetics Ingredients Functions]
SKIN PROTECTING
SKIN CONDITIONING |
| Hazard Information | Back Directory | [Uses]
Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2). Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases[1]. | [References]
[1] Shin JH, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61. DOI:10.1111/j.1471-4159.2012.07771.x |
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