| Identification | Back Directory | [Name]
(R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE
| [CAS]
927819-90-7 | [Synonyms]
(3R)-3-benzyloxypyrrolidine
(R)-3-Benzyloxy Pyrrolidine Hcl
3-phenylmethoxypyrrolidine hydrochloride
(R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE
(3R)-3-(benzyloxy)pyrrolidine hydrochloride | [Molecular Formula]
C11H16ClNO | [MDL Number]
MFCD09261313 | [MOL File]
927819-90-7.mol | [Molecular Weight]
213.71 |
| Hazard Information | Back Directory | [Synthesis]
After N-tert-butoxycarbonyl-(R)-3-benzyloxypyrrolidine separately obtained was dissolved in isopropanol and heated to 40 °C, isopropanol solution of hydrogen chloride was dropped for 6 hours. After the reaction finished, the mixture was cooled to 23 °C and was concentrated to distil the solvent away. Further, ethyl acetate was added and the mixture was concentrated, thereby obtaining a concentrate in an amount of about. Then, the concentrate was heated to 40 °C, and isopropanol was added until (R)-3-benzyloxypyrrolidine hydrochloride which had been separated as an oily substance became completely dissolved. After (R) -3-benzyloxypyrrolidine hydrochloride was crystallized by gradually cooling the solution and suitably adding a seed crystal, hexane was further added. At the time, crystallization solvent was in a following proportion: isopropanol/ethyl acetate/hexane = 1/71.5/71.5. A deposited crystal was subjected to filtration under reduced pressure, and the resultant wet crystal was washed with ethyl acetate, and then a wet crystal was dried under reduced pressure, thereby obtaining dry crystal of (R)-3-benzyloxypyrrolidine hydrochloride (yield of 82 %, purity of 99.8 %).
| [Uses]
(R)-3-Benzyloxy-Pyrrolidine Hydrochloride is an important organic reagent that can be used as a building block for the synthesis of many organic compounds, such as (R)-ethyl 4-(3-(benzyloxy)pyrrolidin-1-yl)butanoate.
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