| Identification | Back Directory | [Name]
5-methyl-N-naphthalen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | [CAS]
92872-51-0 | [Synonyms]
GW648495
GW-648495
GW 648495
5-methyl-N-naphthalen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | [Molecular Formula]
C16H13N5 | [MDL Number]
MFCD01099828 | [MOL File]
92872-51-0.mol | [Molecular Weight]
275.31 |
| Chemical Properties | Back Directory | [Melting point ]
220 °C | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
solid | [pka]
2.96±0.40(Predicted) | [color ]
off-white | [SMILES]
CC1=NC2=NC=NN2C(=C1)NC3=CC4=CC=CC=C4C=C3 |
| Hazard Information | Back Directory | [Description]
GW648495 is an inhibitor of PfDHODH. It shows greater than 4,000-fold selectivity for the malarial enzyme. | [Uses]
PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC50=47 nM). PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals[1]. | [References]
[1] Gujjar R, et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice[J]. Journal of medicinal chemistry, 2009, 52(7): 1864-1872. DOI:10.1021/jm801343r |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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