| Identification | Back Directory | [Name]
15-Lipoxygenase Inhibitor 1 | [CAS]
928853-86-5 | [Synonyms]
4-MMPB
15-Lipoxygenase Inhibitor 1
15-Lipoxygenase Inhibitor I
15-Lipoxygenase Inhibitor 1(4-MMPB)
15-Lipoxygenase Inhibitor 1 Exclusive
4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine | [Molecular Formula]
C16H19N5S | [MOL File]
928853-86-5.mol | [Molecular Weight]
313.421 |
| Chemical Properties | Back Directory | [Boiling point ]
532.1±60.0 °C(Predicted) | [density ]
1.265±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: >5mg/ml | [form ]
A crystalline solid | [pka]
7.17±0.42(Predicted) | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Uses]
4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer[1][2][3][4]. | [Biological Activity]
4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with IC50 value of 18 μM. The IC50 values of it against soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1) were 19.5 μM and 19.1 μM, respectively. It has potential for prostate cancer research. | [in vitro]
4-MMPB has an IC 50 of 69.6 μM for DPPH bleaching.
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
Cell Viability Assay | Cell Line: | DU145 cells, PC-3 cells, HFF3 cells | | Concentration: | 9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM, 159.53 μM | | Incubation Time: | 24 hours, 48 hours, 72 hours | | Result: | IC 50 s of 79.76 μM (24 hours), 51.05 μM (48 hours) and 41.48 μM (72 hours) for PC-3 cells, and 255.25 μM (24 hours), 130.81 μM (48 hours) and 98.91 μM (72 hours) for HFF3 cells. | | [target]
IC50: 18 μM (15-lipoxygenase) | [storage]
Store at -20°C | [References]
[1] M Bakavoli, et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem. 2007 Mar 1;15(5):2120-6. DOI:10.1016/j.bmc.2006.12.022
[2] Mohsen Nikpour, et al. Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism. 2013, 22(10), 5036-5043.
[3] Seyed Jamal Alavi, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018 Jun;91(6):1125-1132. DOI:10.1111/cbdd.13174
[4] Saffiyeh Saboormaleki, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition. Arch Iran Med. 2018 Jun 1;21(6):251-259. PMID:29940744 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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