| Identification | Back Directory | [Name]
1-(3,5-dimethoxybenzoyl)-4-(2-methylphenyl)piperazine | [CAS]
929492-71-7 | [Synonyms]
1-(3,5-dimethoxybenzoyl)-4-(2-methylphenyl)piperazine
Methanone, (3,5-dimethoxyphenyl)[4-(2-methylphenyl)-1-piperazinyl]- | [Molecular Formula]
C20H24N2O3 | [MOL File]
929492-71-7.mol | [Molecular Weight]
340.42 |
| Hazard Information | Back Directory | [Description]
GAC0001E5 is a novel LXR inverse agonist, functioning as LXR a "degrader", significantly reducing LXR protein levels in PDAC cell lines. | [Uses]
GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies[1]. | [References]
[1] Karaboga H, et al. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 Nov 20;15(11):2916-2928. DOI:10.1021/acschembio.0c00546 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
| Company Name: |
OTAVA chemicals
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416 305 9979 (Canada) |
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www.otavachemicals.com |
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Specs
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+31 15 251 8111 |
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www.specs.net |
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