| Identification | Back Directory | [Name]
2-[[4-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO]-4-(4-PYRIDINYL)-5-THIAZOLEMETHANOL | [CAS]
929562-28-7 | [Synonyms]
JNJ1930942
JNJ-1930942
JNJ 1930942
2-[[4-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO]-4-(4-PYRIDINYL)-5-THIAZOLEMETHANOL
5-ThiazoleMethanol, 2-[[4-fluoro-3-(trifluoroMethyl)phenyl]aMino]-4-(4-pyridinyl)-
(2-((4-Fluoro-3-(trifluoromethyl)phenyl)amino)-4-(pyridin-4-yl)thiazol-5-yl)methanol | [Molecular Formula]
C16H11F4N3OS | [MDL Number]
MFCD18642600 | [MOL File]
929562-28-7.mol | [Molecular Weight]
369.34 |
| Hazard Information | Back Directory | [Uses]
JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α(7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282)-evoked rise in intracellular Ca2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice[1]. | [References]
[1] Dinklo T, et al. Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther. 2011;336(2):560-574. DOI:10.1124/jpet.110.173245 |
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