| Identification | Back Directory | [Name]
SGI-110 | [CAS]
929901-49-5 | [Synonyms]
SGI-110
CS-1302
Guadecitabine
SGI110;SGI 110
SGI-110 ammonium salt
SGI-110 Guadecitabine
2'-Deoxy-5-azacytidylyl-(3'-5')-2'-deoxyguanosine
Guanosine, 2'-deoxy-5-azacytidylyl-(3'→5')-2'-deoxy- | [Molecular Formula]
C18H24N9O10P | [MDL Number]
MFCD28144509 | [MOL File]
929901-49-5.mol | [Molecular Weight]
557.41 |
| Chemical Properties | Back Directory | [Boiling point ]
956.4±75.0 °C(Predicted) | [density ]
2.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
H2O | [form ]
Powder | [pka]
1.37±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SGI 110, is a DNA methyltransferases (DNMT) inhibitor. | [in vivo]
Guadecitabine (S110) is effective at retarding tumor growth. While the tumors do not shrink in size with Guadecitabine treatment, they experience very minimal growth while the tumors treated with PBS only show substantial growth. In addition, Guadecitabine induces much less toxicity as determined by mouse weight changes when given subcutaneously (SQ) compare to that with IP injections[3]. | [target]
DNA Methyltransferase | [IC 50]
DNA Methyltransferase |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
NewCan Biotech Limited
|
| Telephone: |
+86-571-86912261 19975279805 |
| Website: |
https://www.newcanbio.com/ |
| Company Name: |
Wuhan Topule
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
NewCan Biotech Limited
|
| Telephone: |
+86-0571-86912261 +86-15658003402 |
| Website: |
https://www.newcanbio.com/ |
|