| Identification | Back Directory | [Name]
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- | [CAS]
930470-97-6 | [Synonyms]
DG70
GSK1733953A
Benzamide, 2-chloro-N-(4',6-dimethoxy[1,1'-biphenyl]-3-yl)-4-fluoro- | [Molecular Formula]
C21H17ClFNO3 | [MDL Number]
MFCD09323000 | [MOL File]
930470-97-6.mol | [Molecular Weight]
385.82 |
| Chemical Properties | Back Directory | [Boiling point ]
452.1±45.0 °C(Predicted) | [density ]
1.295±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.26±0.70(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3]. | [References]
[1] Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440. DOI:10.1021/acsinfecdis.2c00190
[2] Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483. DOI:10.1039/d0ra03206a
[3] Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16. DOI:10.1128/mBio.02022-16 |
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