| Identification | Back Directory | [Name]
4i | [CAS]
930478-88-9 | [Synonyms]
4i
CHEMBL1269981
5-HT3 antagonist-4i
N-(3-CHLORO-2-METHYLPHENYL) QUINOXALIN-2-CARBOXAMIDE
2-Quinoxalinecarboxamide, N-(3-chloro-2-methylphenyl)- | [Molecular Formula]
C16H12ClN3O | [MOL File]
930478-88-9.mol | [Molecular Weight]
297.74 |
| Hazard Information | Back Directory | [Uses]
5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice[1]. | [in vivo]
5-HT3 antagonist 4 (4i) (0.5 and 1mg/kg/day, i.p.; for 4-weeks) ameliorates diabetes-induced depressive-like behavior and serotonin deficits in diabetes mice[1]. | [References]
[1] Deepali Gupta, et al. A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system. Behav Brain Res. 2016 Jan 15;297:41-50. DOI:10.1016/j.bbr.2015.10.007 |
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