| Identification | Back Directory | [Name]
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol | [CAS]
93129-94-3 | [Synonyms]
CB91456900
Tacalcitol monohydrate
24(R)-Dihydroxyvitamin D3
1,24-dihydroxy Vitamin D3 (hydrate)
1,24(R)-DihydroxyvitaMin D3, Monohydrate
1-alpha,24(R)-Dihydroxyvitamin D3 monohydrate
9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol,Monohydrate, (1a,3b,5Z,7E,24R)- (9CI)
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-Methyl-heptan-2-yl]-7a-Methyl-2,3,3a,5,6,7-hexahyd
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate , (1R,3S,5Z)- | [Molecular Formula]
C27H44O3 | [MDL Number]
MFCD13184757 | [MOL File]
93129-94-3.mol | [Molecular Weight]
434.66 |
| Hazard Information | Back Directory | [Description]
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes. 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 μg/g ointment, safely and effectively suppresses psoriasis. It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis. 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor. It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration. | [Uses]
Tacalcitol Monohydrate is used as a vitamin D analog used in combination with Imatinib (G407000) in the therapy of non-small cell lung cancer. It is a COVID19-related research product. | [References]
[1] GIOVANNI LEONE Alessia P. Profile of clinical efficacy and safety of topical tacalcitol.[J]. Acta Biomedica de l”Ateneo Parmense, 2005, 76 1: 13-19.
[2] FRANCESCA PRIGNANO Torello L Gionata Buggiani. Clinical evaluation of topical tacalcitol efficacy in extending the remission period between nb-UVB phototherapy cycles in psoriatic patients.[J]. Acta Biomedica de l”Ateneo Parmense, 2009, 80 1: 51-56.
[3] KUNIO MATSUMOTO. Effect of 1,24R-dihydroxyvitamin D3 on the Growth of Human Keratinocytes[J]. Journal of Dermatology, 1990, 17 2: 97-103. DOI: 10.1111/j.1346-8138.1990.tb03714.x
[4] MASAMI FUKUOKA. Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol)[J]. British Journal of Pharmacology, 2009, 124 7: 1433-1438. DOI: 10.1038/sj.bjp.0701988
[5] K.-I. YAMANAKA. 1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration[J]. British Journal of Dermatology, 2010, 162 6: 1206-1215. DOI: 10.1111/j.1365-2133.2010.09692.x |
| Spectrum Detail | Back Directory | [Spectrum Detail]
(1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-5-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol(93129-94-3)1HNMR
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